Anatomy and Pathology of the Basal Ganglia

The functional anatomy of basal ganglia disorders.

Basal ganglia disorders are a heterogeneous group of clinical syndromes with a common anatomic locus within the basal ganglia. To account for the variety of clinical manifestations associated with insults to various parts of the basal ganglia we propose a model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection...

Emergent basal ganglia pathology within computational models.

Functional Anatomy, Physiology and Clinical Aspects of Basal Ganglia

Ensuring coordination of the nervous system functioning, communication between various structures, adjusting the functions to the changes in internal and external environment depends on processing of substantial amount of information (Groenewegen, 2007; Groenewegen & van Dongen, 2007). The concept of cortico-subcortical loops is one of the explanations of the physiological control of the majori...

Navarro Functional anatomy of thalamus and basal ganglia

Published online: 26 July 2002 © Springer-Verlag 2002 ticofugal projection provides positive feedback to the “correct” input, while at the same time suppressing irrelevant information. Topographical organisation of the thalamic afferents and efferents is contralateral, and the lateralisation of the thalamic functions affects both sensory and motoric aspects. Symptoms of lesions located in the t...

Beyond the Basal Ganglia Widespread pathology in Huntington’s disease

Beyond the Basal Ganglia, widespread pathology in Huntington's disease Huntington's disease (HD) is a fatal, hereditary disorder caused by a mutation in the gene encoding the protein huntingtin. Although mutant huntingtin is ubiquitously expressed throughout the body, HD research has mainly focused on the role of the basal ganglia. Dysfunction of these brain nuclei likely underlies motor distur...